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Cystatin C (F122) Peptide

Cat no: BS3973P

Cystatin C (F122) Peptide

Cystatin C is a cysteine (thiol) protease inhibitor that belongs to the type II cystatin gene superfamily and is the most abundant extracellular inhibitor of cysteine proteases. Cystatin C is a constitutively secreted, amyloidogenic protein, which forms a two-fold symmetric dimer and modulates both cysteine protease activity and the expression of class II MHC molecules. Expression of cystatin C is an indicator of kidney function and glomerular filtration rate. Mutations in the cystatin C gene can lead to protein aggregates, which are implicated in hereditary amyloid angiopathy (HCCAA) and cerebral hemorrhage. Although both wild-type and mutant cystatin C are capable of forming concentration dependent inactive dimers, mutant cystatin C dimerizes at lower concentrations and is more susceptible to serine proteases, which may facilitate aggregation. In neuronal cells, oxidative stress stimulates expression of cystatin C, which may positively regulate apoptosis.

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SPECIFICATIONS

Catalog Number

BS3973P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Cystatin C (F122). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P01034

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3973 Cystatin C (F122) pAb.

Alternative Names

ARMD11; MGC117328;CST3;

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