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Dachshund 1 (Drosophila) (DACH, Dach1, Dachshund homolog 1)

Dachshund 1 (Drosophila) (DACH, Dach1, Dachshund homolog 1)

Cat no: D0900-20

Supplier: United States Biological
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Dachshund is a human homologue of Drosophila melanogaster dachshund, which is a nuclear factor essential for determining cell fates in the eye, leg, and nervous system. Mouse Dachshund protein was immunolocalized to specific cell types within the developing kidneys, eyes, cochleae, and limb buds (1). Dachshund was found to be expressed in breast cancer cell lines and to inhibit transforming growth factor-beta (TGF-beta)-induced apoptosis. Dachshund participates in the negative regulation of TGF-beta signaling by interacting with NCoR and Smad4 (2). Applications: Suitable for use inFlow Cytometry, Western Blot, Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1000 Flow Cytometry: 1:120 Immunoprecipitation: 1:40 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: D0900-20
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Ayres JA, et al. Genomics 77(1-2):18-26, 2001. 2. Wu K, et al. J Biol Chem 278(51):51673-84, 2003
Additional info: Recognizes human Drosophila melanogaster Dachshund 1.

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