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DDB1 (Damage-specific DNA Binding Protein 1)

DDB1 (Damage-specific DNA Binding Protein 1)

Cat no: D1575-01C

Supplier: United States Biological
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Recognizes the large subunit of DNA damage-binding protein-functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). Cellular Localization: Nuclear Positive Control: HeLa, Jurkat and NSO (mouse) cell lysates Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D1575-01C
Reactivities: Human, Mouse, Rat
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: DDB p127 Subunit, DDBa, DNA Damage Binding Protein 1, UV Damaged DNA Binding Protein 1, UV-DDB1, Xeroderma pigmentosum Group E Complementing Protein, XPCE, XPE-BF
References: Nichols AF et al. Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation. J Biol Chem 275:21422-8 (2000). Dualan R et al. Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. Genomics 29:62-9 (1995).
Additional info: Species Crossreactivity: Crossreacts with Human, Rat and Mouse.

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