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DDB2 (Damage-specific DNA Binding Protein 2, FLJ34321)

DDB2 (Damage-specific DNA Binding Protein 2, FLJ34321)

Cat no: D1584-80A

Supplier: United States Biological
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DDB2 is required for expression of an ultraviolet radiation (UV)-damaged DNA-binding activity and is disrupted by mutations in the subset of xeroderma pigmentosum group E cells that lack this activity, DDB-negative XPE. DDB2 is the smaller subunit of a heterodimeric protein implicated in the etiology of xeroderma pigmentosum group E. This subunit appears to be required for DNA binding. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:2000-1:10,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D1584-80A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.01% sodium azide.
P type: Pab
Purity: Purified by delipidation and defibrination.
References: 1. Shiyanov, P., et al., (1999), "Cullin 4A associates with the UV-damaged DNA-binding protein DDB", J. Biol. Chem., 274(50), 35309-35312. 2. Shiyanov, P., et al., (1999), "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription", Mol. Cell Biol., (7), 4935-4943.
Additional info: Recognizes human DDB2 at ~47.8kD.

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