DDR1 (Discoidin Domain Receptor 1, CAK, CD167, EC=2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE)

DDR1 is a DDR/TKT type protein kinase. DDR1 is activated by various types of collagen, including types I through IV. Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation. DDR1 may function in cell-to-cell interaction or recognition. At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919 amino acids, have been reported. DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors.\n\nCellular Localization: C-terminal region of human\n\nPositive Control: Decidual Cells\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D1649-03

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Pab

Purity

Purified by peptide immunoaffinity chromatography.

References

1. Hou G, Vogel WF, and Bendeck MP. Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression. Circ Res (90):1147-9 (2002 Jun)\n2. H&#195;¤mmerle B, Vera-Samper E, Speicher S, Arencibia R, Mart&#195;nez S, and Tejedor FJ. Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions. Dev Biol (246):259-73 (2002 Jun)\n3. Vogel WF. Ligand-induced shedding of discoidin domain receptor 1. FEBS Lett (514):175-80 (2002 Mar)\n4. Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, and McCaughan GW. Insights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis : Analysis of Intrahepatic Differential Gene Expression. Am J Pathol (160):641-654 (2002 Feb)\n5. L&#39;hote CG, Thomas PH, and Ganesan TS. Functional analysis of discoidin domain receptor 1: effect of adhesion on DDR1 phosphorylation. FASEB J (2001 Dec)

Additional Info

This antibody is specific for the human DDR1 protein. Species Crossreactivity: Human. Other species not tested.

Alternative Names

CAK, CD167, EC=2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE