Home  >  Products  >  DDX3, ID (ATP-dependent RNA Helicase DDX3X, DEAD Box Protein 3, X-Chromosomal, Helicase-like Protein 2, HLP2, DEAD Box, X Isoform, DDX3X, DBX)
DDX3, ID (ATP-dependent RNA Helicase DDX3X, DEAD Box Protein 3, X-Chromosomal, Helicase-like Protein 2, HLP2, DEAD Box, X Isoform, DDX3X, DBX)

DDX3, ID (ATP-dependent RNA Helicase DDX3X, DEAD Box Protein 3, X-Chromosomal, Helicase-like Protein 2, HLP2, DEAD Box, X Isoform, DDX3X, DBX)

Cat no: D1660-20J

Supplier: United States Biological
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DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases. DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome. DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation. It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HepG2 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1660-20J
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Linder, P. et al. Nature 337, 121 (1989). 2. Park, SH. et al. Cytogenet. Cell Genet. 81, 178 (1998). 3. Lahn, BT. et al. Science 278, 675 (1997). 4. Abdelhaleem, M. et al. Clin. Biochem. 38, 499 (2005). 5. Chang, PC. et al. Oncogene 25, 1991 (2006). 6. Yedavalli, VS. et al. Cell 119, 381 (2004).
Additional info: Recognizes human DDX3. Species Crossreactivity: mouse and rat.

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