Home  >  Products  >  Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)
Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)

Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)

Cat no: D2675-02B

Supplier: United States Biological
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DAZL is involved in mitosis and meiosis of human germ cells. The DZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DZL transcripts were found to be lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DZL homologous gene function found to be azoospermic, just as with human azoospermia. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Optimal dilutions to be determined by the researcher. Positive Control: Mouse testis lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D2675-02B
Reactivities: Human, Mouse, Bovine, Canine, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Kuo, PL. et.al Fertil. Steril. 81:1034-1040 (2004). 2. Brekhman, V. et al. Mol. Hum. Reprod. 6:465-468 (2000). 3. Teng, YN. et al. J. Clin. Endocr. Metab. 87:5258-5264 (2002).
Additional info: Recognizes mouse DAZL. Species Crossreactivity: chimpanzee, bovine, canine, monkey, human. Species sequence homology: chicken.

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