Home  >  Products  >  Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)
Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)

Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)

Cat no: D2675-02C

Supplier: United States Biological
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DAZL is involved in mitosis and meiosis of human germ cells. The DZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DZL transcripts were found to be lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DZL homologous gene function found to be azoospermic, just as with human azoospermia. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.3ug/ml ELISA: >1:64,000 Optimal dilutions to be determined by the researcher. Positive Control: Human Ovary lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D2675-02C
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Cauffman G, Van de Velde H, Liebaers I, Van Steirteghem A. DAZL expression in human oocytes, preimplantation embryos and embryonic stem cells. Mol Hum Reprod. 2005 Jun;11(6):405-411. Epub 2005 May 6. PMID: 15879466.
Additional info: Recognizes human DAZL. Species sequence homology: mouse, rat, canine.

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