Home  >  Products  >  Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)
Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)

Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)

Cat no: D2728-01D

Supplier: United States Biological
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DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 5-15ug/ml ELISA: 1:3000-1:15000 Western Blot: 1:300-1:1500. Detects a band at ~74kD in pancreatic cell lysates. Optimal dilutions to be determined by the researcher. Positive Control: human ovary Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D2728-01D
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Alternative names: Drosophila Delta Homolog 4
References: 1. Thurston, G. et al. (2007) The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat. Rev. Cancer. 7: 327-331.
Additional info: Recognizes human Delta-like ligand 4 (DLL4). Species Sequence Homology: mouse, rat and chimpanzee.

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