Der1-like Domain Family, Member 1 (DER-1, DER1, DERL1, DERLIN-1, DERTRIN-1, FLJ13784, FLJ42092, MGC3067, PRO2577)

Derlin-1 is a channel-like protein, found in the ER membrane, responsible for degrading and funneling misfolded proteins and other cellular debris into the appropriate degradative pathways within the cell.\n\nCellular Localization: Subcellular localization in the endoplasmic reticulum\n\nPositive Control: KRM (canine microsome) lysates. (BD offers commercial liver microsomes)\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D3206-97B

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Can

Form

As reported

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Ye, Y., et al, A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 429: 841-847 (2004)\n2. Lilley, B.N., & Ploegh, H.L. A membrane protein required for dislocation of misfolded proteins from the ER. Nature 429:834-840, 2004.\n3. Schekman, R. A Channel for protein waste. Nature. 429:817-818, 2004.

Additional Info

This antibody is specific for Derlin-1. Species Crossreactivity: This antibody reacts with human and canine Derlin-1. No other specie has been tested. The immunogen used for this antibody production has 100% homology with human, Xenopus, bovine, and mouse protein.

Alternative Names

Degradation in endoplasmic reticulum protein 1, Der1-like protein 1, DERtrin-1, DERL1