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Desmoplakin 1

Cat no: D3221-89J

Desmoplakin 1

Desmoplakin (DP) is a cytoplasmic plaque protein that is located in desmosomes, which are abundant in tissues subjected to mechanical stress, like muscle and epidermis. The role of DP is to link the transmembrane cadherins via plakoglobin to the cytoplasmic intermediate filament network (Kowalczyk et al. 1997; Smith and Fuchs 1998). DP comprises an N-terminal, desmosome-associated plakin domain binding to plakoglobin and plakophilin (Smith and Fuchs 1998), a central coiled-coil rod domain responsible for dimerization, and a C-terminal domain consisting of three homologous plakin repeat subdomains, named

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SPECIFICATIONS

Catalog Number

D3221-89J

Size

50ul

Applications

IHC, WB

Form

Supplied as a liquid.

P Type

Pab

Purity

Serum

Isotype

IgG

References

Troyanovsky S.M., Troyanovsky R.B., Eshkind L.G., Krutovskikh V.A., Leube R.E. and Franke W.W.: Identification of plakoglobinbinding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage. J.Cell Biol. 127, 151

Additional Info

Shows distinct punctate membrane staining of epithelia. In Western blot analysis the antiserum reacts specifically with the desmoplakin I polypeptide.

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

More info
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