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DFF-a, CT (DNAation Factor, alpha Polypeptide, zgc:92229, Dffa)

DFF-a, CT (DNAation Factor, alpha Polypeptide, zgc:92229, Dffa)

Cat no: D3224-27

Supplier: United States Biological
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DNA fragmentation factor alpha petide (dffa) is a nuclease involved in degrading naked DNA during apoptosis, inducing apoptotic morphology. It was formerly known as caspase-activated Dnase. However, there is little published scientific literature currently available for zebrafish dffa. In humans, dffb is also known as DNA fragmentation factor 45 (DFF-45). Human dffa is capable of triggering DNA fragmentation and chromatin condensation during apoptosis. Additionally, one study demonstrated expression of dffa in human cell lines correlated with DNA fragmentation during apoptosis, and overexpression potentiated DNA fragmentation by apoptotic stimuli. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: D3224-27D Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3224-27
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. http://www.uniprot.org/uniprot/Q9DGL7. 2. Liu, X et al (1998) Proc. Natl. Acad. Sci. USA 95:8461-8466. 3. Mukae, N et al (1998) Proc. Natl. Acad. Sci. USA 95:9123-9128.
Additional info: Recognizes zebrafish DFF-a.

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