Home  >  Products  >  DFF40 (DNA Fragmentation Factor Subunit beta, Caspase-activated Deoxyribonuclease, CAD, Caspase-activated DNase, DNA Fragmentation Factor 40kD Subunit, DFF-40, Dffb, Cad)
DFF40 (DNA Fragmentation Factor Subunit beta, Caspase-activated Deoxyribonuclease, CAD, Caspase-activated DNase, DNA Fragmentation Factor 40kD Subunit, DFF-40, Dffb, Cad)

DFF40 (DNA Fragmentation Factor Subunit beta, Caspase-activated Deoxyribonuclease, CAD, Caspase-activated DNase, DNA Fragmentation Factor 40kD Subunit, DFF-40, Dffb, Cad)

Cat no: D3224-30E

Supplier: United States Biological
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DFF is composed of two subunits: DFF40/CAD and DFF45/ICAD. Human DFF45 and its mouse homolog ICAD are the inhibitors of DFF40 and CAD, respectively. Cleavage of DFF45, which is mediated by caspase-3, leads to DFF40's activation as a nuclease. Activation of DFF40/CAD can lead to DNA fragmentation, a hallmark of apoptosis. DFF40 mRNA is expressed in limited number of human tissues: pancreas, spleen, prostate, and ovary. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunohistochemistry: 2-8ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3224-30E
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes mouse DFF40 at ~43kD. Species Crossreactivity: human and rat.

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