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DGK-0 (S725) Peptide

Cat no: BS2479P

DGK-0 (S725) Peptide

Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-0 is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-0 co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)). DGK-0 is the isoform responsive to alpha-Thrombin stimulation.

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SPECIFICATIONS

Catalog Number

BS2479P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide DGK-0 (S725). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P52824

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2479 DGK-0 (S725) pAb.

Alternative Names

DGKQ; DAGK4; Diacylglycerol kinase theta; DGK-theta

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