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DHS (L87) Peptide

Cat no: BS3847P

DHS (L87) Peptide

Deoxyhypusine synthase (DHS) is crucial for the posttranslational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A (eIF-5A). Hypusine is formed by posttranslational modifications involving two enzymatic steps catalyzed by DHS and deoxyhypusine hydroxylase (DOHH). eIF-5A is essential for eukaryotic cell proliferation. DHS, which belongs to the deoxyhypusine synthase family of proteins, is important for the first step in the hypusine biosynthesis pathway. It acts as a catalyst for the NAD-dependent oxidative cleavage of spermidine and the ensuing transfer of the butylamine moiety of spermidine to the eIF-5A protein, to create the intermediate deoxyhypusine residue.

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SPECIFICATIONS

Catalog Number

BS3847P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide DHS (L87). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P49366

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3847 DHS (L87) pAb.

Alternative Names

Deoxyhypusine synthase; DHPS; DS

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