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DIAPH2 Peptide

Cat no: BS60413P

DIAPH2 Peptide

Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of the Drosophila diaphanous gene, belong to a family of formin homology (FH) proteins which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with Profilin and RhoA in dynamic plasma membrane structures and induces the formation of stress fibers in conjunction with the ROCK-mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed.

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SPECIFICATIONS

Catalog Number

BS60413P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide DIAPH2. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O60879

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS60413 DIAPH2 pAb.

Alternative Names

Protein diaphanous homolog 2; Diaphanous-related formin-2; DRF2; DIA; Diap2; Dia2; Dia 2

SUPPLIER INFO

Bioworld Technology, Inc.

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