Dihydrotestosterone, 5a (5a-DHT, Androstanolone)

Dihydrotestosterone (DHT) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5alpha-reductase by means of reducing the 4,5 double-bond. Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. Androgens are part of the biology of gender by stimulating and controlling the development and maintenance of masculine characteristics. DHT is 3 times more potent than testosterone; testosterone is 5-10 times more potent than adrenal androgens. While DHT is best known for its roles in causing male pattern hair loss and prostate problems, it is crucial to virilization and is necessary to mitigate estrogen's effects in men. DHT is an important contributor to other characteristics generally attributed to males, including facial and body hair growth, and deepening of the voice. Unlike other androgens such as testosterone, DHT cannot be converted by the enzyme aromatase to estradiol. It, therefore, is frequently used in research settings to distinguish between effects of testosterone caused by binding to the androgen receptor, and those caused by testosterone's conversion to estradiol and subsequent binding to estrogen receptors\n\nApplications:\nSuitable for use in RIA. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nTiter: \n~120,000 tests/ml by RIA\n\nAffinity Constant:\n~4.0x10e10 L/mole\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

D8036

Size

1000Tests

Hosts

Rabbit

Form

Supplied as a liquid. No preservatives added.

P Type

Pab

Purity

Serum

Isotype

IgG

References

Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent, Swerdloff, R S : Wang, C., aillieres-Clin-Endocrinol-Metab. 1998 Oct; 12(3): 501-6

Additional Info

Recognizes Dihydrotestosterone: 100%, Testosterone: 5%, Androstane-3a-17b,diol: 0.2%, Androstenedione, Androsterone, Estradiol, Cortisol, Corticosterone, Progesterone, Pregnenolone: <0.01%.