Dipeptidyl Peptidase 10, aa765-779 (DPP10, DPL2, DPPY, DPRP-3, DPRP3, KIAA1492)

A novel gene, DPP10, encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy. The DPP10 protein shares features with members of the S9B family of DPP serine proteases, which includes DPP4, a widely expressed enzyme that plays a central role in chemokine processing as part of the innate immune system. The locus displays a complex pattern of transcript splicing, with eight alternate first exons; four of which localize within the LD block strongly associated with asthma.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA (peptide): 1:32,000\nWestern Blot: 0.1-0.3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D8065-32C

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

P Type

Pab

Purity

Purified by immunoaffinity chromatography

Isotype

IgG

References

Malerba G & Pignatti PF A review of asthma genetics: gene expression studies and recent candidates. J Appl Genet 46:93-104 (2005). PubMed: 15741670

Additional Info

Recognizes human Dipeptidyl Peptidase 10 . Predicted to react with Chicken (86% identity with immunogen), Chimpanzee (100% identity with immunogen), bovine (100% identity with immunogen) and canine (92% identity with immunogen) due to sequence homology.

Alternative Names

DPL2, DPPY, DPRP-3, DPRP3, KIAA1492