Dlx4 (Distal-less Homeobox 4, DII Family Homeodomain Transcription Factor)

DLX (Distal-less) genes are essential for early development. BP1 (beta protein 1) is a homeodomain-containing isoform of DLX4. Strong BP1 expression is seen in placenta and kidney tissue, with no expression found in any other tissue (1). This protein has been shown to be activated in 80% of invasive ductal breast tumors and is associated with breast cancer progression ( 2, 3). It is also expressed in the bone marrows of 63% of acute myeloid leukemia (AML) patients (4). In addition, BP1 plays a role in globin gene regulation by repressing the beta- globin gene (1).\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D3800-04A

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

As reported

P Type

Pab

Purity

Purified by peptide immunoaffinity chromatography.

References

1. Chase, M.B., Fu, S., Haga, S.B., Davenport, G., Stevenson, H., Do, K., Morgan, D., Mah, A., and Berg, P.E. BP1, a homeodomain-containing isoform of DLX4, represses the b-globin gene. Mol. Cell. Biol. 22: 2505-2514, 2002.\n2. Fu, S., Schwartz, A., Stevenson, H., Pinzone, J.J., Davenport, G.J., Orenstein, J.M., Gutierrez, P., Simmens, S., Abraham, J., Poola, I., Stephan, D.A. and Berg, P.E. Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer. Br. Ca. Res. 5:82-87, 2003.\n3. Man, Y-g., Fu, S.W., Schwartz, A., Pinzone, J.J., Simmens, S.J. and Berg, P.E. Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasion. In press, Br. Ca. Res. and Treat.\n4. Haga, S., Fu, S., Karp, J.E., Ross, D.D., Williams, D.M., Hankins, W.D., Behm, F., Ruscetti, F.W., Chang, M., Smith, B.D., Becton, D., Raimondi, S.C. and Berg, P.E. BP1, a new homeobox gene, is frequently expressed in acute leukemias. Leukemia 14: 1867-1875, 2000.

Additional Info

This antibody is specific for human BP1. Species Crossreactivity: This antibody reacts with human protein. The immunogen used for this antibody production has 82% homology with mouse BP1 protein.

Alternative Names

Beta Protein 1 BP1, Distal-less Homeobox 4 (isoform a)