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DMPK (R30) pAb

DMPK (R30) pAb

Cat no: BS2298

Supplier: Bioworld Technology, Inc.
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Myotonic dystrophy protein kinase (DMPK) is a ulti-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis. DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction. DM arises through expansion of CTG repeats in the 3'-UTR of the DMPK gene. Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus. These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype. Other substrates for DMPK include myogenin, Ltype calcium channels, and Phospholemman (PLM).
Catalogue number: BS2298
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q09013
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the N-terminus of Human DMPK.
Species: DMPK (R30) pAb detects endogenous levels of DMPK protein.
Molecular weight: ~ 70 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: DMPK; DM; DM-KINASE; DM1; DM1PK; DMK; EC 2.7.11.1; MDPK; MT-PK
Additional info: For research use only, not for use in diagnostic procedure.

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