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DNA pol (alpha) (K111) pAb

DNA pol (alpha) (K111) pAb

Cat no: BS1922

Supplier: Bioworld Technology, Inc.
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DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol (alpha), (beta), (delta) and E are involved in DNA replication and repair. DNA pol (delta) and DNA pol E are multisubunit enzymes, with DNA pol (delta) consisting of two subunits: p125, which interacts with the sliding DNA clamp protein PCNA; and p50. The nuclear-encoded DNA pol (gamma) is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol (zeta)is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol 0 is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.
Catalogue number: BS1922
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P09884
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 81-130 of Human DNA pol (alpha).
Species: DNA pol (alpha) (K111) pAb detects endogenous levels of DNA pol (alpha) protein.
Molecular weight: ~ 180 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; POLA1; POLA; DNA pol(alpha)
Additional info: For research use only, not for use in diagnostic procedure.

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