DNA pol (delta) 3 pAb

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, exonucleases are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases, namely DNA pol (alpha), (beta), (delta) and E. DNA pol (delta) and DNA pol E are multisubunit enzymes, with DNA pol (delta) consisting of two subunits which interact with the sliding DNA clamp protein PCNA. DNA pol (delta) 3, also known as POLD3 or p66, is a 466 amino acid nuclear protein that is required for the proper function of DNA pol (delta).

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SPECIFICATIONS

Catalog Number

BS5699

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to the 421-466 of Human DNA pol (delta) 3.

Species

DNA pol (delta) 3 pAb detects endogenous levels of DNA pol (delta) 3 protein.

Dilutions

WB: 1:500~1:1000\nICC: 1:50~1:200

Swiss Prot

Q15054

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 51 kDa

Alternative Names

DNA polymerase delta subunit 3; DNA polymerase delta subunit p66; POLD3; KIAA0039; DNA pol (delta)3; DNA pol(delta)3; DNApol(delta)3; DNA pol (delta) p66; DNA pol(delta) p66