Ecdysone (alpha-Ecdysone, BRN 2422986, CCRIS 6931, 2beta,3beta,14alpha,22R,25-Pentahydroxy-5beta-cholest-7-en-6-one)

\nSteroidal prohormone of the major insect molting hormone 20-hydroxyecdysone.\n A member of the ecdysteroid family.\nEcdysone receptor (EcR) agonist.\nInduces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. \nPlays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP).\nAppears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. \nUsed for controlled gene expression in scientific research, agriculture and medicine. \nUsed for the development of selective insect growth regulators for use as environmentally benign insecticides.\n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044769

Size

1mg

Purity

>95% (NMR)

References

Product Reference: \n?Ecdysone, an insect steroid hormone, and its mode of action: P. Karlson & C.E. Sekeris; Recent Prog. Horm. Res. 22, 473 (1966)\n?Ecdysone, the molting hormone of insects: P. Karlson; Naturwissenschaften 53, 445 (1966) (German)\n?Puffs and gene regulation-molecular insights into the Drosophila ecdysone regulatory hierarchy: C.S. Thummel; Bioessays 12, 561 (1990)\n?Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone: A.J. Andres & C.S. Thummel; Trends Genet. 8, 132 (1992) (Review)\n?The IVth Karlson Lecture: ecdysone-responsive genes: P. Cherbas; Insect Biochem. Mol. Biol. 23, 3 (1993)\n?Ecdysone signaling cascade and regulation of Drosophila metamorphosis: E.H. Baehrecke; Arch. Insect Biochem. Physiol. 33, 231 (1996) (Review)\n?Nuclear hormone receptors and the Drosophila ecdysone response: S.R. Russell; Biochem. Soc. Symp. 62, 111 (1996)\n?Ecdysone receptors and their biological actions: L.M. Riddiford, et al.; Vitam. Horm. 60, 1 (2000) \n?Ecdysone-regulated puff genes 2000: C.S Thummel; Insect Biochem. Mol. Biol. 32, 113 (2002)\n?Ecdysone-controlled expression of transgenes: L.D. Graham; Expert Opin. Biol. Ther. 2, 525 (2002)\n?Non-genomic ecdysone effects and the invertebrate nuclear steroid hormone receptor EcR-new role for an \"old\" receptor? U. Schlattner, et al.; Mol. Cell Endocrinol. 247, 64 (2006)\n?Ecdysone and the cell cycle: investigations in a mosquito cell line: A.M. Fallon & A. Gerenday; J. Insect. Physiol. 56, 1396 (2010)\n?

Alternative Names

alpha-Ecdysone, BRN 2422986, CCRIS 6931, 2beta,3beta,14alpha,22R,25-Pentahydroxy-5beta-cholest-7-en-6-one