EDG-2 (W45) pAb

Cat no: BS2695

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.

Catalogue number:	BS2695
Reactivities:	Human, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q92633
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 10-62 of Human EDG-2.
Species:	EDG-2 (W45) pAb detects endogenous levels of EDG-2 protein.
Molecular weight:	~ 38 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	EDG2; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2; EDG2; 1902; EDG2; 602282; Q92633; Gpcr26; LPA1; LPAR1; Mrec1.3; edg-2; rec.1.3; vzg-1;
Additional info:	For research use only, not for use in diagnostic procedure.

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EDG-2 (W45) pAb

Cat no: BS2695

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