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EDG-5 (L303) Peptide

EDG-5 (L303) Peptide

Cat no: BS2594P

Supplier: Bioworld Technology, Inc.
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The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.
Catalogue number: BS2594P
Applications: Block/Neutralize/Inhibit
Swiss prot: O95136
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide EDG-5 (L303). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; S1P receptor Edg-5; S1PR2; EDG5
Additional info: This peptide can be used with studies using BS2594 EDG-5 (L303) pAb.

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