Egr-1/2 (R409) Peptide

Cat no: BS1944P

Supplier: Bioworld Technology, Inc.

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Additional Information

Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92% identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause of Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.

Catalogue number:	BS1944P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P18146/P11161
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Egr-1/2 (R409). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	EGR2; AT591; CMT1D; CMT4E; DKFZP686J1957; EGR-2; FLJ14547; KROX20
Additional info:	This peptide can be used with studies using BS1944 Egr-1/2 (R409) pAb.

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Egr-1/2 (R409) Peptide

Cat no: BS1944P

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