Elongin A1 (R129) Peptide

Cat no: BS2530P

Supplier: Bioworld Technology, Inc.

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Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangio-blastoma of the central nervous system and pheochromo-cytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. The VHL protein migrates with an apparent molecular weight of 38 kDa. The Elongin A subunit is 773 amino acids in length and has an apparent molecular weight of 110 kDa, while Elongin B and C are 18 kDa and 15 kDa proteins, respectively.

Catalogue number:	BS2530P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q14241
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Elongin A1 (R129). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Transcription elongation factor B polypeptide 3; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Elongin A; EloA; Elongin 110 kDa subunit; TCEB3;
Additional info:	This peptide can be used with studies using BS2530 Elongin A1 (R129) pAb.

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Elongin A1 (R129) Peptide

Cat no: BS2530P

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