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ENDOG Peptide

ENDOG Peptide

Cat no: BS60425P

Supplier: Bioworld Technology, Inc.
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Endonuclease G (ENDOG), a nuclear encoded protein, localizes to the mitochondria (1). This sugar-nonspecific nuclease, responsible for major mitochondrial nuclease activity, preferentially cleaves single-stranded DNA(ssDNA). Synthesized as a propeptide with an amino-terminal presequence that targets the nuclease to mitochondria, ENDOG translocates to neuclei on apoptotic stimulation and act as a nuclease without sequence specificity. Both exonucleases and DNase I stimulate the ability of ENDOG to generate double-stranded DNA cleavage products at physiological ionic strengths, suggesting that these activities work in concert with ENDOG in apoptotic cells to ensure efficient DNA breakdown.
Catalogue number: BS60425P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q14249
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide ENDOG. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Endonuclease G, mitochondrial; Endo G
Additional info: This peptide can be used with studies using BS60425 ENDOG pAb.

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