ENPP3 pAb

Ecto-nucleotide pyrophosphatase/phospho-diesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate bonds in deoxynucleotides, NAD, and nucleotide sugars. There exist three closely related proteins in mammalian species: E-NPP1 (PC-1), E-NPP2 (PDNP2), and E-NPP-3, also known as CD203c, each expressed in different cells or at different locations in the same cells. Basophils, a type of major proinflammatory effector cells involved in diverse pathologic reactions, exhibit CD203c expression. For instance, CD203c expression increases in response to a variety of allergens, including cat dander, latex, and bee and wasp venom. Hovever, these allergies are not the only condition associated with CD203c upregulation; CD203c upregulation may also serve as a tumor marker for colon carcinoma.

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SPECIFICATIONS

Catalog Number

BS60438

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

A synthetic peptide corresponding to residues in Human ENPP3.

Species

ENPP3 pAb detects endogenous levels of ENPP3 protein.

Dilutions

WB: 1:500~1:1000\r

Swiss Prot

O14638

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 100 kDa

Alternative Names

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; ENPP 3; ENPP-3; E-NPP3; Phosphodiesterase I beta; PD-Ibeta; Phosphodiesterase I/nucleotide pyrophosphatase 3; CD203c; Alkaline phosphodiesterase I; Nucleotide pyrophosphatase; NPPase; PDNP3