EP4 Receptor (C-Term) Polyclonal PE Antibody

Antigen: human EP4 receptor C-terminal amino acids 459-488 . Host: rabbit . Cross Reactivity: (+) human, mouse, ovine, and rat EP4 receptors; (-) EP1, EP2, and EP3 receptors . Application(s): FC and IF . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cAMP and subsequent relaxation of smooth muscle. In addition to sequence differences, EP4 receptors are distinguished from EP2 receptors by their insensitivity to the EP2 receptor selective agonist butaprost.

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SPECIFICATIONS

Catalog Number

10479

Applications

FC, IF

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Eicosanoids

Weight

0

Antigen

Human amino acids 459-488 (GSGRAGPAPKGSSLQVTFPSETLNLSEKCI)

Storage Temp

4

Shipping Temp

4

Additional Info

The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G protein-coupled EP receptors: EP1, EP2, EP3, and EP4. Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP and subsequent relaxation of smooth muscle. In addition to sequence differences, EP4 receptors are distinguished from EP2 receptors by their insensitivity to the EP2 receptor selective agonist butaprost. The EP4 receptor is expressed in multiple human tissues including kidney, small intestine, thymus, ileum, uterus, and lung, as well as in peripheral blood leukocytes. The receptor is also expressed in cultured human blood cell lines of monocytoid (U937 and THP-1) and lymphoid (MOLT-4, Jurkat, and Raji) origin.