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Epidermal Growth Factor Receptor (erbB, EGFR), Extracellular Domain

Epidermal Growth Factor Receptor (erbB, EGFR), Extracellular Domain

Cat no: E3375-03B

Supplier: United States Biological
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EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4 or HER-1, -2, -3, -4. It binds to epidermal growth factor (EGF), transforming growth factor-a (TGFa), heparin binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head and neck, esophagus, cervix, vulva, ovary and endometrium. It is predominantly present in squamous cell carcinomas. Applications: Suitable for use in ELISA, Immunohistochemistry (paraffin and frozen), and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, ddH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3375-03B
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, pH 7.4, 0.09% sodium azide. Reconstitute with 100ul ddH2O.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Manneck, H.E., et al., (1993), "Enzyme-linked Immunosorbent Assay for the Determination of Epidermal Growth Factor Receptor", Klin. Lab., 39:177-182, 2. Roth, H.J., et al., (1994), "Is it necessary for a Quantitative EGF Receptor Assay to detect the ligand binding site? Comparison of Methods: Radioligand Binding Assay (RLBA vs. IEMA Ligand Binding Site vs IEMA Non-ligand Binding Site)", Klin. Lab., 40:1025-1032.
Additional info: Recognizes human EGF receptor (extracellular non-ligand binding site). Does not cross react with v-erb-B.

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