(-)-Epigallocatechin gallate (Epigallocatechin-3-gallate, CCRIS 3729, Teavigo, NVP-XAA 723)

Potent anticancer compound. Anti-angiogenic. VEGF, VE-cadherin phosphorylation, matrix metalloproteinase and urokinase-plasminogen activator (uPA) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. Modulates chronic inflammatory diseases, such as type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease. COX-2 and inducible nitric oxide synthase (iNOS; NOS II) inhibitor. Potent antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Regulates cancer cell growth, proliferation, transformation, survival, angiogenesis, apoptosis, invasion and metastasis. Chemopreventive. Apoptosis inducer. Promotes cell cycle arrest. Modulates signal transduction pathways including JAK/STAT, MAPK, PI3K/AKT, Wnt and Notch. EGFR and HER-2 receptor signaling inhibitor. MAPKs and activator protein-1 inhibitor. mTOR suppressor. IGF-I signaling inhibitor. Proteasome inhibitor. Telomerase and DNA methyltransferase inhibitor. Selective and noncompetitive HAT inhibitor. Topoisomerase I and II inhibitor. Hedgehog signaling (Hh) modulator. PTCH and Gli1 inhibitor. Wnt signaling inhibitor. Neuroprotective. Activates HO-1 by the ARE/Nrf2 pathway, protecting neurons against oxidative damage. STAT-1 inhibitor. Shows preventive cardiovascular and metabolic (obesity, insulin resistance, hypertension and hypercholesterolemia) effects. Inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins and down-regulates lipogenic enzymes as well as other potential targets. Fatty acid synthase (FAS) inhibitor. \n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C. After reconstitution, prepare aliquots and store at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044775

Size

25mg

Purity

>98% (HPLC)

References

Product Reference: \nMolecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation: Y.J. Surh, et al.; Mutat. Res. 480-481, 243 (2001) (Review)?\nTargeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate: N. Khan, et al.; Cancer Res. 66, 2500 (2006) (Review)?\nInhibition of fatty acid synthase by polyphenols: W.X. Tian; Curr. Med. Chem. 13, 967 (2006) (Review)?\nGreen tea polyphenols as a natural tumour cell proteasome inhibitor: Q.P. Dou, et al.; Inflammopharmacology 16, 208 (2008) (Review)?\nChemoprevention with phytochemicals targeting inducible nitric oxide synthase: A. Murakami; Forum Nutr. 61, 193 (2009) (Review)?\nMolecular basis for cancer chemoprevention by green tea polyphenol EGCG: H. Tachibana; Forum Nutr. 61, 156 (2009) (Review)?\nApoptosis by dietary agents for prevention and treatment of prostate cancer: N. Khan, et al.; Endocr. Relat. Cancer 17, R39 (2010) (Review)?\nTargeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate: E. Melgarejo, et al.; Amino Acids 38, 519 (2010) (Review)?\nGreen tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis: R. Singh, et al.; Life Sci. 86, 907 (2010) (Review)?\nRegulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals: S.C. Gupta, et al.; Cancer Metastasis Rev. 29, 405 (2010) (Review)?\nUpdates of mTOR inhibitors: H. Zhou, et al.; Anticancer Agents Med. Chem. 10, 571 (2010) (Review)?\nThe role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer: F.H. Sarkar, et al.; Cancer Metastasis Rev. 29, 383 (2010) (Review)?\nUse of STAT1 inhibitors in the treatment of brain I/R injury and neurodegenerative diseases: F.H. Ebner, et al.; Cent. Nerv. Syst. Agents Med. Chem. 11, 2 (2011) (Review)?\nWeight control and prevention of metabolic syndrome by green tea: S. Sae-tan, et al.; Pharmacol. Res. 64, 146 (2011) (Review)?\nTargeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer: M.K. Shanmugam, et al.; Nutr. Cancer 63, 161 (2011) (Review)?\nImplications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds: Y. Li, et al.; J. Nutr. Biochem. 22, 799 (2011) (Review)?\nModulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders: G. Scapagnini, et al.; Mol. Neurobiol. 44, 192 (2011) (Review)?\nNutritional approaches to modulate oxidative stress in Alzheimer's disease: C.B. Pocernich, et al.; Curr. Alzheimer Res. 8, 452 (2011) (Review)?\nPossible involvement of programmed cell death pathways in the neuroprotective action of polyphenols: S. Bastianetto, et al.; Curr. Alzheimer Res. 8, 445 (2011) (Review)?\nGreen tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications: B.N. Singh, et al.; Biochem. Pharmacol. 82, 1807 (2011) (Review)?\nEpigenetic diet: impact on the epigenome and cancer: T.M. Hardy & T.O. Tollefsbol; Epigenomics 3, 503 (2011) (Review)?\nGreen tea EGCG, T cells, and T cell-mediated autoimmune diseases: D. Wu, et al.; Mol. Aspects Med 33, 107 (2012) (Review)?\n

Alternative Names

Epigallocatechin-3-gallate, CCRIS 3729, Teavigo, NVP-XAA 723