EpoR (S423) Peptide

Cat no: BS9239P

Supplier: Bioworld Technology, Inc.

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The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

Catalogue number:	BS9239P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P19235
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide EpoR (S423). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Erythropoietin receptor; EPO-R; EPOR
Additional info:	This peptide can be used with studies using BS9239 EpoR (S423) pAb.

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EpoR (S423) Peptide

Cat no: BS9239P

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