ER(beta) (E101) pAb

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER(alpha) and ER(beta), contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ER(alpha) and ER(beta) have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER(alpha) and ER(beta) may be regulated by distinct mechanisms even though they share many functional characteristics.

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SPECIFICATIONS

Catalog Number

AP0436

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 71-120 of Human ER(beta).

Species

ER(beta) (E101) pAb detects endogenous levels of ER(beta) protein.

Dilutions

WB: 1:500~1:1000\r

Swiss Prot

Q92731

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 48, 60 kDa

Alternative Names

DKFZp686N23123; \nER alpha; \nER; \nER-alpha; \nEra; \nESR 1; \nESR; \nESR1; \nESR1; \nESRA; \nEstradiol receptor; \nEstrogen nuclear receptor alpha; \nEstrogen receptor 1; \nEstrogen receptor alpha 3*; 4; 5; 6; 7*/822 isoform; \nEstrogen receptor alpha delta 3*; 4; 5; 6; 7*; 8*/941 isoform; \nEstrogen receptor alpha delta 3*; 4; 5; 6; 7*/819 2 isoform; \nEstrogen receptor alpha delta 4 +49 isoform; \nEstrogen receptor alpha delta 4*; 5; 6; 7*/654 isoform; \nEstrogen receptor alpha delta 4*; 5; 6; 7; 8*/901 isoform; \nEstrogen receptor; \nMajor OR