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ERAB (E135) pAb

ERAB (E135) pAb

Cat no: BS1713

Supplier: Bioworld Technology, Inc.
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(beta)-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer's disease. (beta)-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of (beta)-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated (beta)-Amyloid-binding protein. ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer's disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to (beta)-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that (beta)-Amyloid induced cell death is mediated by ERAB.
Catalogue number: BS1713
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q99714
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 102-150 of Human ERAB.
Species: HADH2 (E135) pAb detects endogenous levels of HADH2 protein.
Molecular weight: ~ 27 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 3-hydroxyacyl-CoA dehydrogenase type-2; EC=1.1.1.35; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; EC=1.1.1.178; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH; ERAB; HADH2; MRPP2; SCHAD; XH98G2; HSD17B10
Additional info: For research use only, not for use in diagnostic procedure.

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