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ErbB-4 (E1280) Peptide

ErbB-4 (E1280) Peptide

Cat no: BS1797P

Supplier: Bioworld Technology, Inc.
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The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
Catalogue number: BS1797P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q15303
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide ErbB-4 (E1280). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: 4ICD; Avian erythroblastic leukemia viral oncogene homolog 4; Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4; E4ICD; EC 2.7.10.1; ErbB4; ERBB4 intracellular domain; ERBB4; HER 4; HER4; Mer4; MGC138404; Oncogene ERBB4; P180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor protein tyrosine kinase erbB 4 precursor; Receptor tyrosine protein kinase erbB 4; s80HER4; Tyrosine kinase type cell surface receptor HER4; Tyrosine kinase-type cell surface receptor HER4; v erb a avi
Additional info: This peptide can be used with studies using BS1797 ErbB-4 (E1280) pAb.

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