ERCC1 (V171) Peptide

Cat no: BS1111P

Supplier: Bioworld Technology, Inc.

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Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5' incisions during DNA repair. The ERCC1-XPF endonuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.

Catalogue number:	BS1111P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P07992
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide ERCC1 (V171). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	DNA excision repair protein ERCC-1; : ERCC1
Additional info:	This peptide can be used with studies using BS1111 ERCC1 (V171) pAb.

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ERCC1 (V171) Peptide

Cat no: BS1111P

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