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EWSR1 Peptide

EWSR1 Peptide

Cat no: BS5715P

Supplier: Bioworld Technology, Inc.
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EWS is a nuclear RNA-binding protein. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1 in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various ETS transcription factors, including Fli-1, Erg, ETV1, E1AF and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. Two functional regions have been identified in EWS; an amino-terminal region (domain A), that has little transactivation activity but transforms efficiently when fused to Fli-1, and a distal region (domain B), which shows transactivation activity but transforms less efficiently when fused to Fli-1.
Catalogue number: BS5715P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q01844
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide EWSR1. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein; EWS
Additional info: This peptide can be used with studies using BS5715 EWSR1 pAb.

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