F12 (HC) pAb

Cat no: BS7026

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).

Catalogue number:	BS7026
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	P00748
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human F12 (HC).
Species:	F12 (HC) pAb detects endogenous levels of Coagulation factor XIIa heavy chain protein.
Molecular weight:	~ 40, 68 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Coagulation factor XII; Hageman factor; HAF; Coagulation factor XIIa heavy chain;
Additional info:	For research use only, not for use in diagnostic procedure.

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F12 (HC) pAb

Cat no: BS7026

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