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F1Aa, CT (Protein Fem-1 Homolog B, FEM1b, FEM1-beta, F1A-alpha, Fem-1-like Death Receptor-binding Protein alpha, Fem-1-like in Apoptotic Pathway Protein alpha, FEM1B, F1AA, KIAA0396)

Cat no: F0001-05A

F1Aa, CT (Protein Fem-1 Homolog B, FEM1b, FEM1-beta, F1A-alpha, Fem-1-like Death Receptor-binding Protein alpha, Fem-1-like in Apoptotic Pathway Protein alpha, FEM1B, F1AA, KIAA0396)

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aa and FEM1b. F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aa is cleaved by CED-3 and caspase. FEM-1/F1Aa associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aa /span>induces apoptosis. F1Aa /span>is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa /span>is expressed in a variety of human and mouse tissues.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F0001-05A

Size

50ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Chan SL, Tan KO, Zhang L, 2. Ventura-Holman T, Maher JF. Sequence, organization, and expression of the human FEM1B gene. Biochem Biophys Res Commun 2000;267(1):317-20.

Additional Info

Recognizes human F1Aa (CT). Species Crossreactivity: mouse and rat.

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