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FAM49B, Recombinant, Human, aa1-324, His-Tag (Protein FAM49B, BM-009, L1)

Cat no: 137052

FAM49B, Recombinant, Human, aa1-324, His-Tag (Protein FAM49B, BM-009, L1)

FAM49B has been provisionally designated FAM49B pending further characterization. In a recent genome-wide transcriptional analysis, It identified a gene signature for multiple sclerosis (MS), which reverted back to normal during pregnancy. Reversion was particularly evident for 7 genes: SOCS2, TNFAIP3, NR4A2, CXCR4, POLR2J, FAM49B, and STAG3L1, most of which encode negative regulators of inflammation. \n\nSource: \nRecombinant protein corresponding to human FAM49B, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~39.1kD (347aa) (MALDI-TOF) \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMGNLLKV LTCTDLEQGP NFFLDFENAQ PTESEKEIYN QVNVVLKDAE GILEDLQSYR GAGHEIREAI QHPADEKLQE KAWGAVVPLV GKLKKFYEFS QRLEAALRGL LGALTSTPYS PTQHLEREQA LAKQFAEILH FTLRFDELKM TNPAIQNDFS YYRRTLSRMR INNVPAEGEN EVNNELANRM SLFYAEATPM LKTLSDATTK FVSENKNLPI ENTTDCLSTM ASVCRVMLET PEYRSRFTNE ETVSFCLRVM VGVIILYDHV HPVGAFAKTS KIDMKGCIKV LKDQPPNSVE GLLNALRYTT KHLNDETTSK QIKSMLQ\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137052

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol 0.1M NaCl, 1mM DTT.

Purity

~90% (SDS-PAGE)

References

1. Francesca Gilli. et al. (2011) Arch Neurol. 68:879-888. 2. Niranjana A Nagarajan. et al. (2012) Nature Immunology. 13:579

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