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FANCD2 (P216) Peptide

FANCD2 (P216) Peptide

Cat no: BS1120P

Supplier: Bioworld Technology, Inc.
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The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC(Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451 amino acid nuclear protein that exists as two protein isoforms.
Catalogue number: BS1120P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q9BXW9
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide FANCD2 (P216). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Fanconi anemia group D2 protein; FACD2; FANCD2; FACD
Additional info: This peptide can be used with studies using BS1120 FANCD2 (P216) pAb.

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