FAP-1 (Tyrosine-protein Phosphatase Non-receptor Type 13, Fas-associated Protein-tyrosine Phosphatase 1, PTP-BAS, Protein-tyrosine Phosphatase 1E, PTP-E1, hPTPE1, Protein-tyrosine Phosphatase PTPL1, PTPN13, PNP1, PTP1E, PTPL1)

A novel protein tyrosine phosphatase, Fap-1 (for FAS- associated phosphatase) (originally designated PTP- BAS), has been shown to associated with the carboxyl terminus 15aa of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485aa in length. Although lacking a transmembrane region, Fap-1 does contain a membrane-binding domain, similar to that found in cytoskeletonassociated proteins such as ezrin. Fap-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 1:100 for 30min at RT\nStaining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10min followed by cooling at RT for 20min.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nPlacenta\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts