FAS (FAS1, ALPS1A, Apo-1 Antigen, Apoptosis-mediating Surface Antigen FAS, APT1, CD95, FASLG Receptor, FASTM, Tumor Necrosis Factor Receptor Superfamily Member 6, TNFRSF6)

CD95, a 45kD Type I transmembrane protein, is a member of TNFR superfamily. It is a multifunctional protein expressed in multiple cell types and consists of an extracellular domain that binds to CD95L and a cytoplasmic domain having the death domain. It plays a key role in regulating immune homeostasis and self-tolerance by mediating lymphocyte apoptosis. It interacts with CD95L with its death domain and forms a death-inducing signaling complex that includes FADD, Caspase-8 and Caspase-10 leading to apoptosis. CD95 also activates NF-kB and MAPK pathways and transduces anti-apoptotic signals in normal diploid fibroblasts and T-cells. CD95 also induces pro-inflammatory signals and maintains immuno-suppressed state in brain and eyes. Pathophysiological role of CD95 has been implicated in malignancies and various degenerative and autoimmune disorders including ALPS.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:25-1:50\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nSmall intestine\n\nCellular Localization: \nCell membrane\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F0019-61T

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Sasaki et al. Br J Urol 81: 852, 1998. 2. Sugihara et al. Anticancer Res 17: 3861, 1997. 3. Kondo et al. J Pathol 183: 75, 1997. 4. Oehm et.al JBC 267 (15) 10709-10715 (May 25, 1992). 5. Choi et.al Brain Research Reviews 44 (1) 65-81 (January 2004).

Additional Info

Recognizes human Fas.

Alternative Names

Fas (TNF Receptor Superfamily, Member 6)