Home  >  Products  >  Fas Ligand (FAS Antigen Ligand, FASL, FASLG, Apoptosis Antigen Ligand, APT1LG1, APTL, CD95 Ligand, CD95L, CD95-L, CD178, Tumor Necrosis Factor Ligand Superfamily Member 6, TNFSF6)
Fas Ligand (FAS Antigen Ligand, FASL, FASLG, Apoptosis Antigen Ligand, APT1LG1, APTL, CD95 Ligand, CD95L, CD95-L, CD178, Tumor Necrosis Factor Ligand Superfamily Member 6, TNFSF6)

Fas Ligand (FAS Antigen Ligand, FASL, FASLG, Apoptosis Antigen Ligand, APT1LG1, APTL, CD95 Ligand, CD95L, CD95-L, CD178, Tumor Necrosis Factor Ligand Superfamily Member 6, TNFSF6)

Cat no: F0019-65

Supplier: United States Biological
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FAS Ligand (FASL) is a 40kD type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. The human FasL gene consists of approximately 8kb and is split into four exons. This gene consists of 281aa with a calculated M(r) of 31,759 and was mapped on chromosome 1q23. It has an identity of 76.9% at the aa sequence level with mouse FasL. The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis. FAS and FASL triggered apoptosis pathway plays an important role in human carcinogenesis. This system may also play a role in modulating the genetic susceptibility of mouse strains to develop T-cell lymphoblastic lymphomas. Applications: Suitable for use in Western Blot, Immunohistochemistry, and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Immunohistochemistry (FFPE): 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F0019-65
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Generalized Lymphoproliferative Disease, GLD, TNF Superfamily Member 6
References: 1. Takahashi T., et al., Int. Immun 6: 1567-1574 (1994) 2. Zhang X, et al., J Med. Genet. 42:479-484 (2005) 3. Villa-Morales M., et al., Cancer Res. 67:5107-5116 (2007)
Additional info: Recognizes human FASL. Species Cross-Reactivity: mouse, rat.

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