Fatty Acid SynthasepAb

Fatty acid biosynthesis is mediated by seven catalytic enzymes and an acyl carrier protein (ACP), to which various acyl intermediates are covalently attached. Fatty Acid Synthase (FAS) is the anabolic enzyme that contains the seven unique catalytic sites and mediates the conversion of acetyl-CoA and malonyl-CoA, in the presence of the cofactor NADPH, into long-chain saturated fatty acids, such as palmitate. Human Fatty Acid Synthase cDNA encodes a 2,504 amino acid protein. Catalytically active Fatty Acid Synthase is a homodimer. Human Fatty Acid Synthase mRNA is variably expressed with abundant levels present in brain, lung and liver. Fatty acid synthetic metabolism is abnormally elevated in tumor cells and may support cell growth or survival of malignant cancers.

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SPECIFICATIONS

Catalog Number

BS6050

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human Fatty Acid Synthase.

Species

FASN pAb detects endogenous levels of FASN protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P49327

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 270 kDa

Alternative Names

[Acyl-carrier-protein] S acetyltransferase; \n[Acyl-carrier-protein] S malonyltransferase; \n[Acyl-carrier-protein] S-acetyltransferase; \n[Acyl-carrier-protein] S-malonyltransferase; \n3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; \n3-oxoacyl-[acyl-carrier-protein] reductase; \n3-oxoacyl-[acyl-carrier-protein] synthase; \nEnoyl-[acyl-carrier-protein] reductase; \nFAS; \nFAS; \nFASN; \nFatty acid synthase; \nMGC14367; \nMGC15706; \nOA 519; \nOleoyl-[acyl-carrier-protein] hydrolase; \nSDR27X1; \nSh