FCGR1A pAb

Three different classes of IgG Fc receptors have been described: Fc(gamma)RI (CD64), Fc(gamma)RII (CD32) and Fc(gamma)RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-(gamma) stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.

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SPECIFICATIONS

Catalog Number

BS6238

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human FCGR1A.

Species

FCGR1A pAb detects endogenous levels of FCGR1A protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P12314

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~39,43 kDa

Alternative Names

CD64; CD64A; Fc fragment of IgG high affinity Ia receptor (CD64); Fc gamma receptor; Fc gamma receptor I A1; Fc gamma RI; Fc gamma RIA; Fc-gamma RI; Fc-gamma RIA; FCG1; FcgammaRIa; FCGR1; FCGR1; FCGR1A; FcRI; FLJ18345; High affinity immunoglobulin gamma Fc receptor I; IGFR1; IgG Fc receptor I;