Fetuin (alpha-2 Heremans-Schmid Glycoprotein, FHSG, Fetuin A)

Fetuin is a 59kD glycoprotein consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly synthesized in liver. It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin occurs in high serum concentrations during fetal life, whereas its level declines following infection, inflamation and malignancy. Fetuin acts as an important circulating inhibitor of ectopic calcification, a frequent complication of many degenerative diseases. Low serum level of Fetuin is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin binds to transforming growth factor-b and blocks TGF-b binding to cell surface receptors.\n\nApplications: \nSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F4102-04

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, pH 7.2. Preservative free. Reconstitute in 100ul of sterile ddH2O. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Arnaud P, Kalabay L. Diabetes Metab Res Rev. 2002; 18(4): 311-4. Review. 2. Ketteler M, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, Bohm R, Metzger T, Wanner C, Jahnen-Dechent W, Floege J. Lancet. 2003; 361(9360): 827-33. 3. Jersmann HP, Dransfield I, Hart SP. Clin Sci (Lond). 2003; 105(3): 273-8. 4. Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, Muller-Esterl W, Schinke T, Jahnen-Dechent W. J Clin Invest. 2003; 112(3): 357-66. 5. Denecke B, Graber S, Schafer C, Heiss A, Woltje M, Jahnen-Dechent W. Biochem J. 2003; 376(Pt 1): 135-45.

Additional Info

Recognizes human fetuin.