Home  >  Products  >  Fibroblast Growth Factor Receptor 1 (FGFR1, Basic Fibroblast Growth Factor Receptor 1, BFGFR, bFGF-R, CD331, CEK, c-fgr, FGFBR, FGFR-1, FLG, FLJ99988, FLT2, Fms-like Tyrosine Kinase 2, H2, H3, H4, H5, HBGFR, KAL2, N-SAM, OGD)
Fibroblast Growth Factor Receptor 1 (FGFR1, Basic Fibroblast Growth Factor Receptor 1, BFGFR, bFGF-R, CD331, CEK, c-fgr, FGFBR, FGFR-1, FLG, FLJ99988, FLT2, Fms-like Tyrosine Kinase 2, H2, H3, H4, H5, HBGFR, KAL2, N-SAM, OGD)

Fibroblast Growth Factor Receptor 1 (FGFR1, Basic Fibroblast Growth Factor Receptor 1, BFGFR, bFGF-R, CD331, CEK, c-fgr, FGFBR, FGFR-1, FLG, FLJ99988, FLT2, Fms-like Tyrosine Kinase 2, H2, H3, H4, H5, HBGFR, KAL2, N-SAM, OGD)

Cat no: F4305-02P

Supplier: United States Biological
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FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml recognizes 10ng recombinant bacterial, baculoviral or native FGFr1. Immunoprecipitation: Native, recombinant and ligand-labeled FGFR1. Immunohistochemistry: Paraffin-embedded human salivary gland tumors Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4305-02P
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 250ug
Form: Supplied as a liquid in PBS, pH 7.4. No preservative added.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Xu, et al., J. Biol. Chem. 267: 14,492 (1992). 2. Wang, et al., J. Biol. Chem. 270: 10,231 (1995).
Additional info: Recognizes both alpha (denatured) and beta isoforms of human Fibroblast Growth Factor Receptor 1. Epitope is within the sequence his241 and val267 between Ig loops II and III. Epitope is masked in undenatured FGFR1-alpha.

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