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FLASH (CASP8-associated Protein 2, FLICE-associated Huge Protein, CASP8AP2, KIAA1315, RIP25)

FLASH (CASP8-associated Protein 2, FLICE-associated Huge Protein, CASP8AP2, KIAA1315, RIP25)

Cat no: F4538-04K

Supplier: United States Biological
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Fas is a cell-surface receptor molecule that relays apoptotic (cell death) signals into cells. When Fas is activated by the binding of its ligand, the proteolytic protein caspase-8 is recruited to a signalling complex known as DISC by binding to a Fas-associated adapter protein. A large new protein, FLASH, has now been identified. This protein contains a motif with oligomerizing activity and another domain (DRD domain) that interacts with a death-effector domain in caspase-8 or in the adapter protein. Stimulated Fas binds FLASH, so FLASH is probably a component of the DISC signalling complex. FLASH is therefore necessary for the activation of caspase-8 in Fas-mediated apoptosis. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 10ug/ml Western Blot: 0.25-0.5ug/ml Immunocytochemistry: 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HeLa Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4538-04K
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Koonin, E.V., et al. Nature. 401:662-3 (1999) 2. Medema J.P., et al. Nature. 398:756-7 (1999) 3. Imai Y., et al. Nature. 398:777-85 (1999).
Additional info: Recognizes human FLASH. Species sequence homology: mouse.

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